Selective Membrane Toxicity of the Polyene Antibiotics: Studies on Natural Membranes
نویسندگان
چکیده
منابع مشابه
Selective membrane toxicity of the polyene antibiotics: studies on lecithin membrane models (liposomes).
In the absence of sterol, amphotericin B at 5 x 10(-6) M caused maximum marker release from the saturated dipalmitoyl lecithin liposomes, minimum release from the unsaturated dioleoyl lecithin liposomes, and an in-between response from egg lecithin liposomes. Nystatin at 2.5 to 4.0 x 10(-5) M induced appreciable marker release from all three types of sterol-free liposomes. The amphotericin B- a...
متن کاملThe Interaction of Polyene Antibiotics with Thin Lipid Membranes
Optically black, thin lipid membranes prepared from sheep erythrocyte lipids have a high dc resistance (R(m) congruent with 10(8) ohm-cm(2)) when the bathing solutions contain NaCl or KCl. The ionic transference numbers (T(i)) indicate that these membranes are cation-selective (T(Na) congruent with 0.85; T(Cl) congruent with 0.15). These electrical properties are independent of the cholesterol ...
متن کاملPenetration of Lipid Monolayers by Polyene Antibiotics. Correlation with Selective Toxicity and Mode of Action.
Previous studies have shown that polyene antibiotics alter permeability in sensitive fungi and thus lead to the loss of essential cytoplasmic constituents, which ultimately culminates in cell death (l-3). Subsequent investigations have led to the contention that the selective toxicity of the polyene antibiotics is due to interaction with a component present only in the membrane of sensitive org...
متن کاملPenetration of Lipid Monolayers by Polyene Antibiotics CORRELATIOS WITH SELECTIVE TOXICITY AND MODE OF ACTION*
Previous studies have shown that polyene antibiotics alter permeability in sensitive fungi and thus lead to the loss of essential cytoplasmic constituents, which ultimately culminates in cell death (l-3). Subsequent investigations have led to the contention that the selective toxicity of the polyene antibiotics is due to interaction with a component present only in the membrane of sensitive org...
متن کاملThe polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1973
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.4.3.316